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Article

Successful treatment of canine leukocyte adhesion deficiency by foamy virus vectors.

Nature medicine - 1 Jan 2008

Bauer Thomas R, Allen James M, Hai Mehreen, Tuschong Laura M, Khan Iram F, Olson Erik M, Adler Rima L, Burkholder Tanya H, Gu Yu-Chen, Russell David W, Hickstein Dennis D

Abstract excerpt

Recent successes in treating genetic immunodeficiencies have demonstrated the therapeutic potential of stem cell gene therapy. However, the use of gammaretroviral vectors in these trials led to insertional activation of nearby oncogenes and leukemias in some study subjects, prompting studies of modified or alternative vector systems. Here we describe the use of foamy virus vectors to treat canine leukocyte...

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Share to Antigens, CD34
Share to Bone Marrow Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukocyte-Adhesion Deficiency Syndrome

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Source

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Identifiers

PMID: 18157138
DOI: 10.1038/nm1695
PMCID: PMC4675671

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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