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Article

Canine neutrophil dysfunction caused by downregulation of beta2-integrin expression without mutation.

Veterinary immunology and immunopathology - 15 Aug 2009

Kobayashi Saori, Sato Reeko, Abe Yuya, Inanami Osamu, Yasui Hironobu, Omoe Katsuhiko, Yasuda Jun, Hankanga Careen, Oda Shinichi, Sasaki Juso

Abstract excerpt

Canine leukocyte adhesion deficiency (CLAD) in Irish setters is caused by genetic defects of leukocyte integrin CD18 leading to recurrent bacterial infections. We report clinical features and analysis of neutrophil function from two mixed-breed canine littermates (one female and one male dog) similar to CLAD. The symptoms of pyogenic infection were first recognized at 3 months of age and since then the patients...

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PMID: 19297030
DOI: 10.1016/j.vetimm.2009.02.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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