Article
Canine leukocyte adhesion deficiency colony for investigation of novel hematopoietic therapies.
Veterinary immunology and immunopathology - 15 Jul 2003
Creevy Kate E, Bauer Thomas R, Tuschong Laura M, Embree Lisa J, Colenda Lyn, Cogan Kevin, Starost Matthew F, Haskins Mark E, Hickstein Dennis D
Abstract excerpt
The genetic immunodeficiency disease canine leukocyte adhesion deficiency (CLAD) was originally described in juvenile Irish Setters with severe, recurrent bacterial infections. CLAD was subsequently shown to result from a mutation in the leukocyte integrin CD18 subunit which prevents leukocyte surface expression of the CD11/CD18 complex. We describe the development of a mixed-breed CLAD colony with clinical...
Topics
- Animals
- Breeding
- CD18 Antigens
- Dog Diseases
- Dogs
- Female
- Genotype
- Heterozygote
- Leukocyte-Adhesion Deficiency Syndrome
- Male
- Minisatellite Repeats
- Mutation
- Pedigree
- Phenotype