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Article

Canine leukocyte adhesion deficiency colony for investigation of novel hematopoietic therapies.

Veterinary immunology and immunopathology - 15 Jul 2003

Creevy Kate E, Bauer Thomas R, Tuschong Laura M, Embree Lisa J, Colenda Lyn, Cogan Kevin, Starost Matthew F, Haskins Mark E, Hickstein Dennis D

Abstract excerpt

The genetic immunodeficiency disease canine leukocyte adhesion deficiency (CLAD) was originally described in juvenile Irish Setters with severe, recurrent bacterial infections. CLAD was subsequently shown to result from a mutation in the leukocyte integrin CD18 subunit which prevents leukocyte surface expression of the CD11/CD18 complex. We describe the development of a mixed-breed CLAD colony with clinical...

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PMID: 12842608
DOI: 10.1016/s0165-2427(03)00057-6

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