Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lentiviral Gene Therapy for Severe Leukocyte Adhesion Deficiency Type 1

1 May 2025

Abstract excerpt

Background The β 2 common integrin subunit CD18 is essential for leukocyte–endothelial adhesion and extravasation to inflamed or infected tissue. Damaging variants in ITGB2 , which encodes CD18, cause leukocyte adhesion deficiency type I (LAD-I), an inborn error of immunity that leads to frequent life-threatening infections and a high risk of death among affected children. Allogeneic hematopoietic stem-cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hematopoietic Stem Cell Transplantation
Share to Skin and Cellular Biology Research
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40305711
DOI: 10.1056/nejmoa2407376

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lentiviral Gene Therapy for Severe Leukocyte Adhesion Deficiency Type 1PMID 40305711Read ↗

An atypical adolescent case of leukocyte adhesion deficiency I caused by a novel ITGB2 splicing variant with successful immune reconstitution following hematopoietic stem cell transplantation.Semantic proximity Read ↗

Clinical and laboratory findings in patients with leukocyte adhesion deficiency type I: A multicenter study in Turkey.Semantic proximity Read ↗

Allogeneic hematopoietic stem cell transplantation in leukocyte adhesion deficiency type I and III.Semantic proximity Read ↗

Leukocyte adhesion deficiency syndromes: adhesion and tethering defects involving beta 2 integrins and selectin ligands.Semantic proximity Read ↗

Clinical and Laboratory Findings in Patients with Leukocyte Adhesion Deficiency Type I: A Multicenter Study in TurkeySemantic proximity Read ↗

Gene Therapy for Canine Leukocyte Adhesion Deficiency with Lentiviral Vectors Using the Murine Stem Cell Virus and Human Phosphoglycerate Kinase PromotersSemantic proximity Read ↗

Molecular characterization of leukocyte adhesion deficiency-I in Indian patients: identification of 9 novel mutations.Semantic proximity Read ↗

A novel ITGB2 variant with long survival in patients with leukocyte adhesion defect type-I.Semantic proximity Read ↗

Novel ITGB2 Mutation Is Responsible for a Severe Form of Leucocyte Adhesion Deficiency Type 1.Semantic proximity Read ↗

Conversion of the severe to the moderate disease phenotype with donor leukocyte microchimerism in canine leukocyte adhesion deficiency.Semantic proximity Read ↗

Clinical and Genetic Spectrum of a Large Cohort of Patients With Leukocyte Adhesion Deficiency Type 1 and 3: A Multicentric Study From India.Semantic proximity Read ↗

Leukocyte adhesion deficiency type 1 (LAD-1)/variant. A novel immunodeficiency syndrome characterized by dysfunctional beta2 integrins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.