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Article

Leukocyte adhesion deficiency in children and Irish setter dogs.

Pediatric research - 1 Mar 2004

Bauer Thomas R, Gu Yu-Chen, Creevy Kate E, Tuschong Laura M, Embree Lisa, Holland Steven M, Sokolic Robert A, Hickstein Dennis D

Abstract excerpt

Children with the genetic immunodeficiency disease leukocyte adhesion deficiency, or LAD, develop life-threatening bacterial infections as a result of the inability of their leukocytes to adhere to the vessel wall and migrate to the sites of infection. Recently, the canine counterpart to LAD, known as canine leukocyte adhesion deficiency, or CLAD, has been described in Irish setter dogs. This review describes how...

Topics

Animals
Child
Disease Models, Animal
Dogs
Genetic Therapy
Hematopoietic Stem Cell Transplantation
Humans
Leukocyte-Adhesion Deficiency Syndrome
Phenotype

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 14711903
DOI: 10.1203/01.PDR.0000111287.74989.1B

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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