Nonmyeloablative conditioning with busulfan before matched littermate bone marrow transplantation results in reversal of the disease phenotype in canine leukocyte adhesion deficiency.

doi:10.1016/j.bbmt.2005.07.011

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Article

Nonmyeloablative conditioning with busulfan before matched littermate bone marrow transplantation results in reversal of the disease phenotype in canine leukocyte adhesion deficiency.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation - 1 Oct 2005

Sokolic Robert A, Bauer Thomas R, Gu Yu-Chen, Hai Mehreen, Tuschong Laura M, Burkholder Tanya, Colenda Lyn, Bacher John, Starost Matthew F, Hickstein Dennis D

Abstract excerpt

Leukocyte adhesion deficiency (LAD)-1, a primary immunodeficiency disease caused by molecular defects in the leukocyte integrin CD18 molecule, is characterized by recurrent, life-threatening bacterial infections. Myeloablative hematopoietic stem cell transplantation is the only curative treatment for LAD-1. Recently, canine LAD (CLAD) has been shown to be a valuable animal model for the preclinical testing of...

Topics

Animals
Bone Marrow Transplantation
Busulfan
Cyclosporine
Dog Diseases
Dogs
Follow-Up Studies
Immunosuppressive Agents
Leukocyte-Adhesion Deficiency Syndrome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mycophenolic Acid

Phenotype

Transplantation Chimera

Transplantation Conditioning

Treatment Outcome

Source

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Identifiers

PMID: 16182176
DOI: 10.1016/j.bbmt.2005.07.011
PMCID: PMC1351378

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