Article
The role of Streptococcus pneumoniae sortase A in colonisation and pathogenesis.
Microbes and infection - 1 Jan 2006
Paterson Gavin K, Mitchell Tim J
Abstract excerpt
Sortase enzymes are found throughout Gram-positive bacteria and are responsible for the covalent attachment of specific proteins to the cell wall. Through the anchoring of these cell wall proteins, sortase enzymes are important in the ability of several Gram-positive pathogens to cause disease. Previously, deletion of srtA from Streptococcus pneumoniae (the pneumococcus) was shown to disturb the localisation of...
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