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Article

Compensatory regulation among ER chaperones in C. elegans.

FEBS letters - 6 Jun 2005

Kapulkin Wadim J, Kapulkin Vadim, Hiester Brian G, Link Christopher D

Abstract excerpt

We have identified a particularly clear case of compensatory transcriptional regulation among ER chaperones in Caenorhabditis elegans using a GFP reporter transgene that is under the control of the promoter of hsp-4, a C. elegans homolog of GRP-78/BiP. Knockdown by RNA interference of 9 known or predicted ER chaperones induced hsp-4 upregulation via the ire-1/xbp-1 signaling cascade employed in the unfolded...

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PMID: 15907843
DOI: 10.1016/j.febslet.2005.04.062

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GRP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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