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Article

Chromosomal aberrations involving telomeres in BRCA1 deficient human and mouse cell lines.

Cytogenetic and genome research - 1 Jan 2005

Al-Wahiby S, Slijepcevic P

Abstract excerpt

Cells defective in BRCA1 show genomic instability as evidenced by increased radiosensitivity, the presence of chromosomal abnormalities and the loss of heterozygosity at many loci. Reported chromosomal abnormalities in BRCA1 deficient cells include dicentric chromosomes. Dicentric chromosomes, in some cases, may arise as a result of end-to-end chromosome fusions, which represent signatures of telomere...

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Source

Identifiers

PMID: 15905643
DOI: 10.1159/000084208

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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