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Article

The Dicentric Chromosome dic(20;22) Is a Recurrent Abnormality in Myelodysplastic Syndromes and Is a Product of Telomere Fusion.

Cytogenetic and genome research - 1 Jan 2016

MacKinnon Ruth N, Duivenvoorden Hendrika M, Campbell Lynda J, Wall Meaghan

Abstract excerpt

We describe a recurrent dicentric chromosome formed by telomere fusion between chromosome 20 and chromosome 22 in 4 cases of myelodysplastic syndromes (MDS) or acute myeloid leukaemia (AML). In particular, the presence of residual telomere sequences at the site of translocation in 3 of the 4 cases makes a compelling case for telomere fusion. This is the first description of a recurrent telomere fusion event in...

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Share to Chromosome Aberrations
Share to Chromosomes, Human, Pair 20

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to In Situ Hybridization, Fluorescence

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Share to Polymorphism, Single Nucleotide

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Source

Identifiers

PMID: 28259884
DOI: 10.1159/000456677

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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