Article
tRNA actively shuttles between the nucleus and cytosol in yeast.
Science (New York, N.Y.) - 1 Jul 2005
Takano Akira, Endo Toshiya, Yoshihisa Tohru
Abstract excerpt
Previous evidence suggested that transfer RNAs (tRNAs) cross the nuclear envelope to the cytosol only once after maturing in the nucleus. We now present evidence for nuclear import of tRNAs in yeast. Several export mutants accumulate mature tRNAs in the nucleus even in the absence of transcription. Import requires energy but not the Ran cycle. These results indicate that tRNAs shuttle between the nucleus and cytosol.
Topics
- Active Transport, Cell Nucleus
- Adenosine Triphosphate
- Cell Nucleus
- Cytosol
- Introns
- Mutation
- RNA Precursors
- RNA, Fungal
- RNA, Transfer
- RNA, Transfer, Amino Acid-Specific
- RNA, Transfer, Amino Acyl