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Article

Nuclear export of ribosomal subunits.

Trends in biochemical sciences - 1 Nov 2002

Johnson Arlen W, Lund Elsebet, Dahlberg James

Abstract excerpt

The partitioning of cells by a nuclear envelope ensures that precursors of ribosomes do not interact prematurely with other components of the translation machinery. Ribosomal subunits are assembled in nucleoli and exported to the cytoplasm in a CRM1/Ran-GTP-dependent fashion. Export of the large (60S) subunit requires a shuttling adaptor protein, NMD3, which binds to mature, correctly folded subunits. Immature or...

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Share to Receptors, Cytoplasmic and Nuclear
Share to Active Transport, Cell Nucleus
Share to Exportin 1 Protein

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12417134
DOI: 10.1016/s0968-0004(02)02208-9

Genes

NMD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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Nuclear export of ribosomal subunits.PMID 12417134Read ↗

Nmd3p is a Crm1p-dependent adapter protein for nuclear export of the large ribosomal subunit.Semantic proximity Read ↗

Coordinated nuclear export of 60S ribosomal subunits and NMD3 in vertebrates.Semantic proximity Read ↗

Mapping the functional domains of yeast NMD3, the nuclear export adapter for the 60 S ribosomal subunit.Semantic proximity Read ↗

Release of the export adapter, Nmd3p, from the 60S ribosomal subunit requires Rpl10p and the cytoplasmic GTPase Lsg1p.Semantic proximity Read ↗

Nuclear export of 60s ribosomal subunits depends on Xpo1p and requires a nuclear export sequence-containing factor, Nmd3p, that associates with the large subunit protein Rpl10p.Semantic proximity Read ↗

The mRNA export factor Npl3 mediates the nuclear export of large ribosomal subunits.Semantic proximity Read ↗

The putative GTPases Nog1p and Lsg1p are required for 60S ribosomal subunit biogenesis and are localized to the nucleus and cytoplasm, respectively.Semantic proximity Read ↗

Coupled GTPase and remodelling ATPase activities form a checkpoint for ribosome export.Semantic proximity Read ↗

Factors affecting nuclear export of the 60S ribosomal subunit in vivo.Semantic proximity Read ↗

Yvh1 is required for a late maturation step in the 60S biogenesis pathway.Semantic proximity Read ↗

Requirements for the nuclear export of the small ribosomal subunit.Semantic proximity Read ↗

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