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Article

Complex control of mouse apolipoprotein B gene expression revealed by targeted duplication.

Biochimica et biophysica acta - 15 May 2005

Hinsdale Myron E, Maeda Nobuyo

Abstract excerpt

An elevated plasma level of apolipoprotein B-containing lipoproteins is a risk factor for atherosclerotic cardiovascular disease. Subtle genetic abnormalities in gene expression including an increased expression of the APOB gene may play an important role in determining overall risk. In an attempt to increase mouse Apob expression, we used gene targeting and duplicated approximately 65 kb of genomic DNA...

Topics

Animals
Apolipoproteins B
Dietary Fats
Female
Gene Dosage
Gene Duplication
Gene Expression Regulation
Gene Targeting
Genotype
Humans
Lipids
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Inbred C57BL

Source

Identifiers

PMID: 15904874
DOI: 10.1016/j.bbalip.2005.03.002

Genes

APOB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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