Article
Modification of BRCA1- and BRCA2-associated breast cancer risk by AIB1 genotype and reproductive history.
Cancer research - 15 Jul 2001
Rebbeck T R, Wang Y, Kantoff P W, Krithivas K, Neuhausen S L, Godwin A K, Daly M B, Narod S A, Brunet J S, Vesprini D, Garber J E, Lynch H T, Weber B L, Brown M
Abstract excerpt
Women who have inherited a germ-line mutation in the BRCA1 or BRCA2 (BRCA1/2) genes have a greatly increased risk of developing breast cancer compared with the general population. However, there is also substantial interindividual variability in the occurrence of breast cancer among BRCA1/2 mutation carriers. We hypothesize that genes involved in endocrine signaling may modify the BRCA1/2-associated age-specific...
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