Immunoglobulin light-chain genes in the rhesus macaque I: kappa light-chain germline sequences for subgroups IGKV1, IGKV and IGKV3.

doi:10.1007/s00251-005-0794-2

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Article

Immunoglobulin light-chain genes in the rhesus macaque I: kappa light-chain germline sequences for subgroups IGKV1, IGKV and IGKV3.

Immunogenetics - 1 May 2005

Howard Wendy A, Bible Jon M, Finlay-Dijsselbloem Eva, Openshaw Sam, Dunn-Walters Deborah K

Abstract excerpt

The combined processes of immunoglobulin (IG) gene rearrangement and somatic hypermutation allow for the creation of an extremely diverse antibody repertoire. Knowledge of the germline sequence of the IG genes is required so that hypermutation and the affinity matured humoral response can be properly studied. Variable region genes can be arranged into subgroups; in humans, there are 11 IGLV subgroups and six IGKV...

Topics

Alleles
Amino Acid Sequence
Animals
Antibody Diversity
Base Sequence
DNA
Gene Rearrangement, B-Lymphocyte, Light Chain
Genes, Immunoglobulin
Immunoglobulin kappa-Chains
In Vitro Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Macaca mulatta

Molecular Sequence Data

Open Reading Frames

Phylogeny

Polymerase Chain Reaction

Sequence Homology, Amino Acid

Somatic Hypermutation, Immunoglobulin

Species Specificity

Source

Open in PubMed

Identifiers

PMID: 15900492
DOI: 10.1007/s00251-005-0794-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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