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Article

Reconstitution of heterochromatin-dependent transcriptional gene silencing.

Molecular cell - 24 Sept 2009

Johnson Aaron, Li Geng, Sikorski Timothy W, Buratowski Stephen, Woodcock Christopher L, Moazed Danesh

Abstract excerpt

Heterochromatin assembly in budding yeast requires the SIR complex, which contains the NAD-dependent deacetylase Sir2 and the Sir3 and Sir4 proteins. Sir3 binds to nucleosomes containing deacetylated histone H4 lysine 16 (H4K16) and, with Sir4, promotes spreading of Sir2 and deacetylation along t...

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Source

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Identifiers

PMID: 19782027
DOI: 10.1016/j.molcel.2009.07.030
PMCID: PMC2842978

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19782027-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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