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Article

Identification of a mutation in porcine ryanodine receptor associated with malignant hyperthermia.

Science (New York, N.Y.) - 26 Jul 1991

Fujii J, Otsu K, Zorzato F, de Leon S, Khanna V K, Weiler J E, O'Brien P J, MacLennan D H

Abstract excerpt

Malignant hyperthermia (MH) causes neurological, liver, and kidney damage and death in humans and major economic losses in the swine industry. A single point mutation in the porcine gene for the skeletal muscle ryanodine receptor (ryr1) was found to be correlated with MH in five major breeds of lean, heavily muscled swine. Haplotyping suggests that the mutation in all five breeds has a common origin. Assuming...

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Source

Identifiers

PMID: 1862346
DOI: 10.1126/science.1862346

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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