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Article

Malignant hyperthermia and excitation-contraction coupling.

Acta physiologica Scandinavica - 1 Mar 2001

Melzer W, Dietze B

Abstract excerpt

Malignant hyperthermia (MH) is a state of elevated skeletal muscle metabolism that may occur during general anaesthesia in genetically pre-disposed individuals. Malignant hyperthermia results from altered control of sarcoplasmic reticulum (SR) Ca2+ release. Mutations have been identified in MH-susceptible (MHS) individuals in two key proteins of excitation-contraction (EC) coupling, the Ca2+ release channel of...

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Identifiers

PMID: 11412150
DOI: 10.1046/j.1365-201x.2001.00840.x

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