Prognostic role of thymidylate synthase polymorphisms in gastric cancer patients treated with surgery and adjuvant chemotherapy.

doi:10.1158/1078-0432.CCR-04-2428

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Article

Prognostic role of thymidylate synthase polymorphisms in gastric cancer patients treated with surgery and adjuvant chemotherapy.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 May 2005

Kawakami Kazuyuki, Graziano Francesco, Watanabe Go, Ruzzo Annamaria, Santini Daniele, Catalano Vincenzo, Bisonni Renato, Arduini Federica, Bearzi Italo, Cascinu Stefano, Muretto Pietro, Perrone Giuseppe, Rabitti Carla, Giustini Lucio, Tonini Giuseppe, Pizzagalli Francesca, Magnani Mauro

Abstract excerpt

PURPOSE: To investigate the prognostic role of thymidylate synthase (TS) polymorphisms in gastric cancer patients treated with radical surgery and fluorouracil-based adjuvant chemotherapy. EXPERIMENTAL DESIGN: Ninety gastric cancer cases were identified among 187 patients previously enrolled in prospective case-control studies for disease susceptibility. Patients were genotyped for a G/C nucleotide change within...

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PMID: 15897576
DOI: 10.1158/1078-0432.CCR-04-2428

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