Article
Thymidylate synthetase (TS) genotype and TS/dihydropyrimidine dehydrogenase mRNA level as an indicator in determining chemosensitivity to 5-fluorouracil in advanced gastric carcinoma.
Anticancer research - 1 Jan 2000
Toriumi Fumiki, Kubota Tetsuro, Saikawa Yoshiro, Yoshida Masashi, Otani Yoshihide, Watanabe Masahiko, Kumai Koichiro, Kitajima Masaki
Abstract excerpt
BACKGROUND: One of the target enzymes of 5-fluorouracil (5-FU) is thymidylate synthetase (TS). The DNA sequence of the TS gene includes either double or triple tandem 28-bp repeats within the promoter region, such that TS genotypes can be classified as homozygous 3R/3R heterozygous 2R/3R or homozygous 2R/2R Several recent studies have shown that TS genotype affects mRNA expression, with 3R/3R homozygotes showing...
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