Article
Polymorphisms in the vascular endothelial growth factor gene and breast cancer in the Cancer Prevention Study II cohort.
Breast cancer research : BCR - 1 Jan 2006
Jacobs Eric J, Feigelson Heather Spencer, Bain Elizabeth B, Brady Kerri A, Rodriguez Carmen, Stevens Victoria L, Patel Alpa V, Thun Michael J, Calle Eugenia E
Abstract excerpt
INTRODUCTION: Vascular endothelial growth factor (VEGF) plays a central role in promoting angiogenesis and is over-expressed in breast cancer. At least four polymorphisms in the VEGF gene have been associated with changes in VEGF expression levels: -2578C/A, -1154G/A and -634G/C are all located in the promoter region; and +936C/T is located in the 3'-untranslated region. METHOD: We examined the association...
Topics
- Breast Neoplasms
- Cohort Studies
- Female
- Humans
- Middle Aged
- Neoplasm Invasiveness
- Neovascularization, Pathologic
- Polymorphism, Genetic
- Polymorphism, Single Nucleotide
- Postmenopause