Article
Recurrent co-alteration of HDGF and SETDB1 on chromosome 1q drives cutaneous melanoma progression and poor prognosis.
Pigment cell & melanoma research - 1 May 2021
Fazio Maurizio, van Rooijen Ellen, Mito Jeffrey K, Modhurima Rodsy, Weiskopf Erika, Yang Song, Zon Leonard I
Abstract excerpt
A progressive increase in copy number variation (CNV) characterizes the natural history of cutaneous melanoma progression toward later disease stages, but our understanding of genetic drivers underlying chromosomal arm-level CNVs remains limited. To identify candidate progression drivers, we mined the TCGA SKCM dataset and identified HDGF as a recurrently amplified gene whose high mRNA expression correlates with...
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