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Article

Regulatory on/off minimization of metabolic flux changes after genetic perturbations.

Proceedings of the National Academy of Sciences of the United States of America - 24 May 2005

Shlomi Tomer, Berkman Omer, Ruppin Eytan

Abstract excerpt

Predicting the metabolic state of an organism after a gene knockout is a challenging task, because the regulatory system governs a series of transient metabolic changes that converge to a steady-state condition. Regulatory on/off minimization (ROOM) is a constraint-based algorithm for predicting the metabolic steady state after gene knockouts. It aims to minimize the number of significant flux changes (hence...

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PMID: 15897462
DOI: 10.1073/pnas.0406346102
PMCID: PMC1140402

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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