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Article

RELATCH: relative optimality in metabolic networks explains robust metabolic and regulatory responses to perturbations.

Genome biology - 5 Jul 2012

Kim Joonhoon, Reed Jennifer L

Abstract excerpt

Predicting cellular responses to perturbations is an important task in systems biology. We report a new approach, RELATCH, which uses flux and gene expression data from a reference state to predict metabolic responses in a genetically or environmentally perturbed state. Using the concept of relative optimality, which considers relative flux changes from a reference state, we hypothesize a relative metabolic flux...

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Identifiers

PMID: 23013597
DOI: 10.1186/gb-2012-13-9-r78
PMCID: PMC3506949

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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