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Article

Impaired long-trace eyeblink conditioning in a Tg2576 mouse model of Alzheimer's disease.

Neuroscience letters - 6 Jan 2012

Kishimoto Yasushi, Oku Ikuko, Nishigawa Atsuko, Nishimoto Akiko, Kirino Yutaka

Abstract excerpt

Eyeblink conditioning has been used for assessing cognitive performance in cases of human neurodegenerative diseases including Alzheimer's disease (AD). Here, we tested and compared the delay and long-trace interval (TI=500ms) eyeblink conditionings in a Tg2576 mouse model of AD, at the age of 3, 6, and 12 months. Tg2576 mice exhibited significant impairment in trace conditioning at 6 months of age. In contrast,...

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Identifiers

PMID: 22085694
DOI: 10.1016/j.neulet.2011.10.071

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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