Article
Kinetic differences in cardiac myosins with identical loop 1 sequences.
The Journal of biological chemistry - 9 Feb 2001
Pereira J S, Pavlov D, Nili M, Greaser M, Homsher E, Moss R L
Abstract excerpt
The kinetics of nucleotide turnover vary considerably among isoforms of vertebrate type II myosin, possibly due to differences in the rate of ADP release from the nucleotide binding pocket. Current ideas about likely mechanisms by which ADP release is regulated have focused on the hyperflexible surface loops of myosin, i.e. loop 1 (ATPase loop) and loop 2 (actin binding loop). In the present study, we...
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