Article
Retrograde regulation of multidrug resistance in Saccharomyces cerevisiae.
Gene - 18 Jul 2005
Moye-Rowley W S
Abstract excerpt
Communication between the mitochondria and the nucleus is essential to ensure correct metabolic coordination of the cell. Signaling pathways leading from the mitochondria to the nucleus are referred to as retrograde signaling and were first discovered in the yeast Saccharomyces cerevisiae. Cells that lack their mitochondrial genome (rho0 cells) trigger expression of the nuclear CIT2 gene in order to ensure...
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