Article
Chronic endoplasmic reticulum stress activates unfolded protein response in arterial endothelium in regions of susceptibility to atherosclerosis.
Circulation research - 28 Aug 2009
Civelek Mete, Manduchi Elisabetta, Riley Rebecca J, Stoeckert Christian J, Davies Peter F
Abstract excerpt
RATIONALE: Endothelial function and dysfunction are central to the focal origin and regional development of atherosclerosis; however, an in vivo endothelial phenotypic footprint of susceptibility to atherosclerosis preceding pathological change remains elusive. OBJECTIVE: To conduct a comparative multi-site genomics study of arterial endothelial phenotype in atherosusceptible and atheroprotected regions. METHODS...
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