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Article

Prelesional arterial endothelial phenotypes in hypercholesterolemia: universal ABCA1 upregulation contrasts with region-specific gene expression in vivo.

American journal of physiology. Heart and circulatory physiology - 1 Jan 2010

Civelek Mete, Grant Gregory R, Irolla Chrysta R, Shi Congzhu, Riley Rebecca J, Chiesa Oscar A, Stoeckert Christian J, Karanian John W, Pritchard William F, Davies Peter F

Abstract excerpt

Atherosclerosis originates as focal arterial lesions having a predictable distribution to regions of bifurcations, branches, and inner curvatures where blood flow characteristics are complex. Distinct endothelial phenotypes correlate with regional hemodynamics. We propose that systemic risk factors modify regional endothelial phenotype to influence focal susceptibility to atherosclerosis. Transcript profiles of...

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Share to Arteries
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cholesterol, Dietary

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Source

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Identifiers

PMID: 19897713
DOI: 10.1152/ajpheart.00652.2009
PMCID: PMC2806137

Genes

ABCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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