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Article

The protein folding network indicates that the ultrafast folding mutant of villin headpiece subdomain has a deeper folding funnel.

The Journal of chemical physics - 28 May 2011

Lei Hongxing, Chen Changjun, Xiao Yi, Duan Yong

Abstract excerpt

Protein folding is a dynamic process with continuous transitions among different conformations. In this work, the dynamics in the protein folding network of villin headpiece subdomain (HP35) has been investigated based on multiple reversible folding trajectories of HP35 and its ultrafast folding mutant where sub-angstrom folding was achieved. The four folding states were clearly separated on the network,...

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PMID: 21639484
DOI: 10.1063/1.3596272
PMCID: PMC3124538

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