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Article

CD8 T cells control cytomegalovirus latency by epitope-specific sensing of transcriptional reactivation.

Journal of virology - 1 Nov 2006

Simon Christian O, Holtappels Rafaela, Tervo Hanna-Mari, Böhm Verena, Däubner Torsten, Oehrlein-Karpi Silke A, Kühnapfel Birgit, Renzaho Angélique, Strand Dennis, Podlech Jürgen, Reddehase Matthias J, Grzimek Natascha K A

Abstract excerpt

During murine cytomegalovirus (mCMV) latency in the lungs, most of the viral genomes are transcriptionally silent at the major immediate-early locus, but rare and stochastic episodes of desilencing lead to the expression of IE1 transcripts. This low-frequency but perpetual expression is accompanied by an activation of lung-resident effector-memory CD8 T cells specific for the antigenic peptide 168-YPHFMPTNL-176,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16928768
DOI: 10.1128/JVI.01248-06
PMCID: PMC1641801

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GCA

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Source receipt: pubmed, retrieved 7 Sept 2026.

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