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Article

Ablation of the regulatory IE1 protein of murine cytomegalovirus alters in vivo pro-inflammatory TNF-alpha production during acute infection.

PLoS pathogens - 1 Jan 2012

Rodríguez-Martín Sara, Kropp Kai Alexander, Wilhelmi Vanessa, Lisnic Vanda Juranic, Hsieh Wei Yuan, Blanc Mathieu, Livingston Andrew, Busche Andreas, Tekotte Hille, Messerle Martin, Auer Manfred, Fraser Iain, Jonjic Stipan, Angulo Ana, Reddehase Matthias J, Ghazal Peter

Abstract excerpt

Little is known about the role of viral genes in modulating host cytokine responses. Here we report a new functional role of the viral encoded IE1 protein of the murine cytomegalovirus in sculpting the inflammatory response in an acute infection. In time course experiments of infected primary macrophages (MΦs) measuring cytokine production levels, genetic ablation of the immediate-early 1 (ie1) gene results in a...

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Source

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Identifiers

PMID: 22952450
DOI: 10.1371/journal.ppat.1002901
PMCID: PMC3431344

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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