Strain-specific T-cell suppression and protective immunity in patients with chronic hepatitis C virus infection.

doi:10.1128/JVI.79.11.6976-6983.2005

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Article

Strain-specific T-cell suppression and protective immunity in patients with chronic hepatitis C virus infection.

Journal of virology - 1 Jun 2005

Sugimoto Kazushi, Kaplan David E, Ikeda Fusao, Ding Jin, Schwartz Jonathan, Nunes Frederick A, Alter Harvey J, Chang Kyong-Mi

Abstract excerpt

Hepatitis C virus (HCV) frequently persists with an apparently ineffective antiviral T-cell response. We hypothesized that some patients may be exposed to multiple HCV subtypes and that strain-specific T cells could contribute to the viral dynamics in this setting. To test this hypothesis, CD4 T-cell responses to three genotype 1a-derived HCV antigens and HCV antibody serotype were examined in chronically HCV...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15890937
DOI: 10.1128/JVI.79.11.6976-6983.2005
PMCID: PMC1112102

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.