Article
Evidence for lack of cross-genotype protection of CD4+ T cell responses during chronic hepatitis C virus infection.
Clinical and experimental immunology - 1 Jan 2003
Harcourt G C, Lucas M, Godkin A J, Kantzanou M, Phillips R E, Klenerman P
Abstract excerpt
CD4+ T lymphocyte responses are thought to play a major role in control of the hepatitis C virus (HCV). Few, however, have been mapped down to the level of peptide and HLA restriction. Furthermore, the ability of such T cells to respond to viruses which differ in genotype has not been addressed in detail. In most cases of persistent infection with HCV, CD4 proliferative responses are weak or absent. From a large...
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