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Selective Replication of Coronavirus Genomes That Express Nucleocapsid Protein

12 May 2005

Abstract excerpt

The coronavirus nucleocapsid (N) protein is a structural protein that forms a ribonucleoprotein complex with genomic RNA. In addition to its structural role, it has been described as an RNA-binding protein that might be involved in coronavirus RNA synthesis. Here, we report a reverse genetic approach to elucidate the role of N in coronavirus replication and transcription. We found that human coronavirus 229E...

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PMID: 15890900
DOI: 10.1128/jvi.79.11.6620-6630.2005

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