Article
Complementary Mutations in the N and L Proteins for Restoration of Viral RNA Synthesis.
Journal of virology - 15 Nov 2018
Li Weike, Gumpper Ryan H, Uddin Yusuf, Schmidt-Krey Ingeborg, Luo Ming
Abstract excerpt
During viral RNA synthesis by the viral RNA-dependent RNA polymerase (vRdRp) of vesicular stomatitis virus, the sequestered RNA genome must be released from the nucleocapsid in order to serve as the template. Unveiling the sequestered RNA by interactions of vRdRp proteins, the large subunit (L) and the phosphoprotein (P), with the nucleocapsid protein (N) must not disrupt the nucleocapsid assembly. We noticed...
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