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Article

Conditional overexpression of transgenes in megakaryocytes and platelets in vivo.

Blood - 1 Sept 2005

Nguyen Hao G, Yu Guangyao, Makitalo Maria, Yang Dan, Xie Hou-Xiang, Jones Matthew R, Ravid Katya

Abstract excerpt

Megakaryocyte (MK)-specific transgene expression has proved valuable in studying thrombotic and hemostatic processes. Constitutive expression of genes, however, could result in altered phenotypes due to compensatory mechanisms or lethality. To circumvent these limitations, we used the tetracycline/doxycycline (Tet)-off system to conditionally over-express genes in megakaryocytes and platelets in vivo. We...

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Identifiers

PMID: 15890684
DOI: 10.1182/blood-2005-02-0638
PMCID: PMC1895218

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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