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Article

Mitochondrial retrograde signaling inhibits the survival during prolong S/G2 arrest in Saccharomyces cerevisiae.

Oncotarget - 29 Dec 2015

Zyrina Anna N, Sorokin Maksim I, Sokolov Sviatoslav S, Knorre Dmitry A, Severin Fedor F

Abstract excerpt

Cell senescence is dependent on the arrest in cell cycle. Here we studied the role of mitochondrial retrograde response signaling in yeast cell survival under a prolonged arrest. We have found that, unlike G1, long-term arrest in mitosis or S phase results in a loss of colony-forming abilities. Consistent with previous observations, loss of mitochondrial DNA significantly increased the survival of arrested cells....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Fungal

Share to G2 Phase Cell Cycle Checkpoints

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Source

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Identifiers

PMID: 26624981
DOI: 10.18632/oncotarget.6406
PMCID: PMC4792543

Genes

MKS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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