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Article

Antiviral activity and in vitro mutation development pathways of MK-6186, a novel nonnucleoside reverse transcriptase inhibitor.

Antimicrobial agents and chemotherapy - 1 Jun 2012

Lu Meiqing, Felock Peter J, Munshi Vandna, Hrin Renee C, Wang Ying-Jie, Yan Youwei, Munshi Sanjeev, McGaughey Georgia B, Gomez Robert, Anthony Neville J, Williams Theresa M, Grobler Jay A, Hazuda Daria J, McKenna Philip M, Miller Michael D, Lai Ming-Tain

Abstract excerpt

MK-6186 is a novel nonnucleoside reverse transcriptase inhibitor (NNRTI) which displays subnanomolar potency against wild-type (WT) virus and the two most prevalent NNRTI-resistant RT mutants (K103N and Y181C) in biochemical assays. In addition, it showed excellent antiviral potency against K103N and Y181C mutant viruses, with fold changes (FCs) of less than 2 and 5, respectively. When a panel of 12 common...

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PMID: 22391531
DOI: 10.1128/AAC.00102-12
PMCID: PMC3370804

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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