Article
HIV-1 subtype C drug-resistance background among ARV-naive adults in Botswana.
Antiviral chemistry & chemotherapy - 1 Jan 2005
Bussmann Hermann, Novitsky Vladimir, Wester William, Peter Trevor, Masupu Kereng, Gabaitiri Lesego, Kim Soyeon, Gaseitsiwe Simane, Ndungú Thumbi, Marlink Richard, Thior Ibou, Essex Max
Abstract excerpt
Current HIV-1 antiretroviral (ARV) drug resistance knowledge is limited to HIV-1 subtype B (HIV-1B). We addressed whether unique genetic and phenotypic properties of HIV-1 subtype C (HIV-1C), southern Africa's most prevalent subtype, may foment earlier and/or distinct resistance mutations. Population-level HIV-1C genotypes were evaluated with respect to drug resistance prevalence before Botswana's public ARV...
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