Article
Molecular characterisation of hepatitis B virus in HIV-1 subtype C infected patients in Botswana.
BMC infectious diseases - 13 Aug 2015
Anderson Motswedi, Gaseitsiwe Simani, Moyo Sikhulile, Wessels Matthijs J C, Mohammed Terence, Sebunya Theresa K, Powell Eleanor A, Makhema Joseph, Blackard Jason T, Marlink Richard, Essex Max, Musonda Rosemary M
Abstract excerpt
BACKGROUND: Hepatitis B virus (HBV) is a major global health problem especially in sub-Saharan Africa and in East Asia. Ten hepatitis B virus genotypes have been described that differ by geographic distribution, disease progression, and response to treatment. Escape mutations within the surface open reading frame (ORF) affect HBV antigenicity leading to failures in diagnosis, vaccine and hepatitis B...
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