Fostemsavir resistance-associated polymorphisms in HIV-1 subtype C in a large cohort of treatment-naïve and treatment-experienced individuals in Botswana.

doi:10.1128/spectrum.01251-23

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Fostemsavir resistance-associated polymorphisms in HIV-1 subtype C in a large cohort of treatment-naïve and treatment-experienced individuals in Botswana.

Microbiology spectrum - 12 Dec 2023

Zuze Boitumelo J L, Radibe Botshelo T, Choga Wonderful T, Bareng Ontlametse T, Moraka Natasha O, Maruapula Dorcas, Seru Kedumetse, Mokgethi Patrick, Mokaleng Baitshepi, Ndlovu Nokuthula, Kelentse Nametso, Pretorius-Holme Molly, Shapiro Roger, Lockman Shahin, Makhema Joseph, Novitsky Vlad, Seatla Kaelo K, Moyo Sikhulile, Gaseitsiwe Simani

Abstract excerpt

IMPORTANCE: Fostemsavir (FTR) is a newly licensed antiretroviral drug that has been shown to have activity against HIV-1. The mechanism of action of FTR is different from all currently available antiretrovirals (ARVs), and as such, it offers hope for HIV-1 suppression in those people with HIV (PWH) who harbor HIV-1 variants with drug resistance mutations to currently used ARVs. Using 6,030 HIV-1 sequences...

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PMID: 37823653
DOI: 10.1128/spectrum.01251-23
PMCID: PMC10714836

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