Article
Prevalence of drug-resistance-associated mutations in antiretroviral drug-naive Zambians infected with subtype C HIV-1.
AIDS research and human retroviruses - 1 Feb 2003
Handema Ray, Terunuma Hiroshi, Kasolo Francis, Kasai Hirotake, Sichone Moses, Yamashita Atsuya, Deng Xuewen, Mulundu Georgina, Ichiyama Kouji, Munkanta Mwansa, Yokota Tomoyuki, Wakasugi Naomi, Tezuka Fumiaki, Yamamoto Naoki, Ito Masahiko
Abstract excerpt
The ability of HIV-1 to evolve resistance to antiretroviral drugs leads to treatment failure. By nucleotide sequencing of HIV-1 subtype B isolates, amino acids responsible for drug resistance have been identified. Less information is available, however, on the extent and distribution of these amino acids in HIV-1 nonsubtype B viruses circulating mainly in developing countries. More HIV-infected patients in the...
Topics
- Adolescent
- Adult
- Amino Acid Sequence
- Anti-HIV Agents
- DNA, Viral
- Drug Resistance, Viral
- Genotype
- HIV Infections
- HIV Protease
- HIV Reverse Transcriptase