Article
CX3CR1 receptor polymorphisms, Th1 cell recruitment, and acute myocardial infarction outcome: looking for a link.
BioMed research international - 1 Jan 2013
Pucci S, Mazzarelli P, Zonetti M J, Fisco T, Bonanno E, Spagnoli L G, Mauriello A
Abstract excerpt
Fractalkine is a proinflammatory chemokine that participates in atherosclerotic process mediating the interactions of vascular cells and leukocytes and selective recruitment of Th1 lymphocytes, through interaction with CX3CR1 receptor. The polymorphism of the fractalkine receptor 280M-containing haplotype, which codifies for a receptor with minor expression and with a reduced binding capability, represents a...
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