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Article

Deletion of <i>IRF-1</i> , Mapping to Chromosome 5q31.1, in Human Leukemia and Preleukemic Myelodysplasia

12 Feb 1993

Abstract excerpt

One of the most frequent cytogenetic abnormalities in human leukemia and myelodysplasia is an interstitial deletion within chromosome 5q. A tumor suppressor gene has been hypothesized to lie in 5q31, the smallest commonly deleted region. IRF-1, a gene whose product manifests anti-oncogenic activity, was mapped to 5q31.1. IRF-1 lies between IL-5 and CDC25C and is centromeric to IL-3 and GM-CSF. Among these genes,...

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Identifiers

PMID: 8438156
DOI: 10.1126/science.8438156

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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