Article
Requirement of HSM3 gene for spontaneous mutagenesis in Saccharomyces cerevisiae.
Mutation research - 4 Oct 2004
Fedorova I V, Kovaltzova S V, Gracheva L M, Evstuhina T A, Korolev V G
Abstract excerpt
In this work, we studied the influence of hsm3 mutation on spontaneous mutagenesis in actively and slowly dividing cells. We demonstrated that the spontaneous mutation rates in the hsm3 mutant and the wild type strain were similar in actively dividing cells. However, during 15-day cultivation of both strains we observed higher accumulation of mutants in the hsm3 strain compared with those in the wild type cells....
Topics
- Genes, Fungal
- Molecular Chaperones
- Mutation
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins