Article
Crystallin {gamma}B-I4F mutant protein binds to {alpha}-crystallin and affects lens transparency.
The Journal of biological chemistry - 1 Jul 2005
Liu Haiquan, Du Xin, Wang Meng, Huang Qingling, Ding Linlin, McDonald Hayes W, Yates John R, Beutler Bruce, Horwitz Joseph, Gong Xiaohua
Abstract excerpt
A new mouse mutant line, Clapper, identified from N-ethyl-N-nitrosurea (ENU)-mutagenized mice, develops a dominant lamellar cataract. The cataract blocks the image of retinal fundus and transmits a fuzzy fluorescein image of retinal vasculature during angiography. The cataractous lens opacity decreases as the mice age. The Clapper mutation has been identified to be a missense mutation of the gammaB-crystallin...
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