Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The gamma S-crystallin gene is mutated in autosomal recessive cataract in mouse.

Genomics - 1 Jul 2002

Bu Lei, Yan Shunsheng, Jin Meilei, Jin Yiping, Yu Chuan, Xiao Shangxi, Xie Qinglian, Hu Landian, Xie Yong, Solitang Yeerjiang, Liu Jing, Zhao Guoping, Kong Xiangyin

Abstract excerpt

We established a recessive cataract model from a spontaneous mutation in the KUNMING outbred mice. Lens opacity appears 11 days after birth. Slit lamp examination reveals that the opacity mainly localizes to the nuclear region of the lens. Histological analysis shows a severe degeneration of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cataract
Share to Crystallins
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to gamma-Crystallins

Share to Genes, Recessive

Share to Glutathione Transferase

Share to Lens, Crystalline

Share to Polymorphism, Single-Stranded Conformational

Source

Identifiers

PMID: 12079281
DOI: 10.1006/geno.2002.6803

Genes

CRYGS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12079281-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The gamma S-crystallin gene is mutated in autosomal recessive cataract in mouse.PMID 12079281Read ↗

Mouse models of cataract.Semantic proximity Read ↗

A temperature-sensitive mutation of Crygs in the murine Opj cataract.Semantic proximity Read ↗

Genetic and allelic heterogeneity of Cryg mutations in eight distinct forms of dominant cataract in the mouse.Semantic proximity Read ↗

Dense nuclear cataract caused by the gammaB-crystallin S11R point mutation.Semantic proximity Read ↗

Gamma-S crystallin gene (CRYGS) mutation causes dominant progressive cortical cataract in humans.Semantic proximity Read ↗

V76D mutation in a conserved gD-crystallin region leads to dominant cataracts in mice.Semantic proximity Read ↗

CRYβA3/A1-Crystallin Knockout Develops Nuclear Cataract and Causes Impaired Lysosomal Cargo Clearance and Calpain Activation.Semantic proximity Read ↗

Arginine 54 and Tyrosine 118 residues of {alpha}A-crystallin are crucial for lens formation and transparency.Semantic proximity Read ↗

Mutation screening of γ-crystallin gene in congenital cataract patients from North India.Semantic proximity Read ↗

Congenital hereditary cataracts.Semantic proximity Read ↗

Genetics of crystallins: cataract and beyond.Semantic proximity Read ↗

Progressive juvenile-onset punctate cataracts caused by mutation of the gammaD-crystallin gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.