Article
Mitochondrial disease: mutations and mechanisms.
Neurochemical research - 1 Mar 2004
McKenzie Matthew, Liolitsa Danae, Hanna Michael G
Abstract excerpt
The mitochondrial diseases encompass a diverse group of disorders that can exhibit various combinations of clinical features. Defects in mitochondrial DNA (mtDNA) have been associated with these diseases, and studies have been able to assign biochemical defects. Deficiencies in mitochondrial oxidative phosphorylation appear to be the main pathogenic factors, although recent studies suggest that other mechanisms...
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