Article
Phenotypic variation in frontotemporal dementia and parkinsonism linked to chromosome 17.
Dementia and geriatric cognitive disorders - 1 Jan 2004
van Swieten John C, Rosso Sonia M, van Herpen Esther, Kamphorst Wouter, Ravid Rivka, Heutink Peter
Abstract excerpt
Hereditary frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) caused by mutations in the tau gene shows a wide range in age at onset, several distinct clinical presentations, and a spectrum of tau pathology. Although the clinical and pathological phenotype often correlate with the location of the mutation, there also exists considerable interfamilial and intrafamilial phenotypical...
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